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Probiotic (Lactobacillus Plantarum) Found to Delay and Reverse Age-Related Skin Damage

Date Posted October 13th, 2016
Probiotic (Lactobacillus Plantarum) Found to Delay and Reverse Age-Related Skin Damage

Many of our most common diseases – obesity, depression, anxiety, Alzheimer’s, autism spectrum disorders, diabetes, heart disease, to name just a few, are associated with changes in the number and type of microbes (bacteria, viruses, yeast, etc.) that live in the gut (decreased gut microbial diversity).  This condition leads to leaky gut and chronic-low grade inflammation (“metaflammation”).

The beneficial effects of probiotics have been thoroughly identified and widely accepted.  Data from research in animals and humans have shown that regular use of probiotics can help many conditions:

  • Gastro-intestinal disorders such as GERD, IBS, constipation, diarrhea, bloating, burping
  • Frequent infections
  • Obesity
  • Fatigue
  • Low mood
  • Brain Fog
  • Chronic inflammation

What About the Use of Probiotics for Anti-Aging Benefits?

Although there are only a few studies of their anti-aging effects, one specific strain, Lactobacillus plantarum, has been shown to exert anti-aging benefits in skin – improved hydration, decreased wrinkles, and reversal of sun-damage. 

Results of a recent double blind, placebo-controlled clinical trial, published in the Journal of Microbiology and Biotechnology, has confirmed these benefits.  The trial comprised 110 volunteers aged 41 and 59 years who had dry skin and wrinkles. Study participants took either L. plantarum or placebo daily for 12 weeks.  Measures of skin aging - skin hydration, wrinkles, skin gloss, and skin elasticity - were measured at baseline and then again every 4 weeks during the study period.

There were significant increases in the skin water content in the face (p < 0.01) and hands (p < 0.05) at week 12 in the probiotic group. Trans-epidermal water loss was suppressed to a greater extent in the face and forearm in the probiotic group at week 12.  Volunteers in the probiotic group had a significant reduction in wrinkle depth at week 12, and skin gloss was also significantly improved by week 12. Finally, skin elasticity in the probiotic group improved by 13.17% (p < 0.05 vs. controls) after 4 weeks and by 21.73% (p < 0.01 vs. controls) after 12 weeks. Authors of the study concluded that, “These findings are preliminary confirmation of the anti-aging benefit to the skin of L. plantarum HY7714 as a nutricosmetic agent.”

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UltraFlora Spectrum by Metagenics


Shi LH, Balakrishnan K, Thiagarajah K, Mohd Ismail NI, Yin OS. Trop Life Sci Res. 2016 Aug;27(2):73-90.


Lee DE, Huh CS, Ra J, Choi ID, Jeong JW, Kim SH, Ryu JH, Seo YK, Koh JS, Lee JH, Sim JH, Ahn YT. J Microbiol Biotechnol. 2015 Dec 28;25(12):2160-8.

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