Items ($0.00)   View Cart Checkout

Probiotic Strain - Bifidobacterium longum - in Triflora Reduces Symptoms of Depression in Adults With Irritable Bowel Syndrome (IBS)

Home / Blog / Probiotic Strain - Bifidobacterium longum - in Triflora Reduces Symptoms of Depression in Adults With Irritable Bowel Syndrome (IBS)


Recent research out of McMaster University has shown that a core strain found in our Triflora probiotic – Bifidobacterium longum – may lessen symptoms of depression and relieve gastrointestinal upset. 

Investigators from the Farncombe Family Digestive Health Research Institute discovered that twice as many adults suffering from irritable bowel syndrome (IBS) experienced improvements in their symptoms of depression when they took a specific probiotic than those who took a placebo.  These findings were published in the Journal of Gastroenterology.

According to the study’s lead author, Dr. Premysl Bercik, the findings provide additional proof that the microbiota environment in the intestines communicates directly with the brain:

"This study shows that consumption of a specific probiotic [Bifidobacterium longum] can improve both gut symptoms and psychological issues in IBS. This opens new avenues not only for the treatment of patients with functional bowel disorders but also for patients with primary psychiatric diseases."

The study included 44 adults with IBS and mild to moderate anxiety or depression. Subjects were followed for 10 weeks;  half took a daily dose of the probiotic Bifidobacterium longum NCC3001, while the others had a daily placebo.

At the end six weeks, twice as many subjects taking the probiotic had decreased depression scores, as compared to patients that had been given placebo (64% versus 32%).

Moreover, neuroimaging studies (Functional Magnetic Resonance Imaging - fMRI) showed that the improvement in depression scores was associated with changes in multiple brain areas involved in the regulation of mood:  “These improvements were associated with changes in brain activation patterns that indicate that this probiotic reduces limbic reactivity.”

For several years, Dr. Dave has been writing and lecturing about the Gut-Brain Connection (Probioitics Shown to Help Women Lose Weight, Probioitcs, Depression, Anxiety, and Obesity, Microbes for Mental Health).  Probiotics have long been a mainstay of many of the treatment protocols we use to address a wide variety of inflammation-driven symptoms including those associated with contemporary diseases of civilization: heart disease, diabetes, anxiety, dementias, depression, obesity, cancer, stroke, MS, Parkinson’s, pain, psoriasis, arthritis, fibromyalgia, chronic fatigue, and so forth.

For these and other reasons, we remain very proud of our best-selling multi-strain probioitc: Triflora.


  1. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: a Pilot Study in Patients With Irritable Bowel Syndrome. Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berner B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P. Gastroenterology. 2017 May 5. pii: S0016-5085(17)35557-9. doi: 10.1053/j.gastro.2017.05.003.
2002-2019 All rights reserved.
Stay Connected: Facebook