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Calcium D-Glucarate 90c by Douglas Laboratories

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$62.80
SKUAM0117
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Calcium D-Glucarate 90c by Douglas Laboratories is a natural supplement of D-glucaric acid bound to calcium. Calcium D-Glucarate may be a useful dietary supplement for those who wish to supplement their diet with D-glucaric acid as a precursor to D-glucaro- 1, 4-lactone. Calcium D-glucarate enhances the body's natural defenses against environmental toxins and excess steroid hormones. Through the actions of its metabolite D-glucaro-1,4-lactone, calcium-d-glucarate indirectly favors glucuronidation, an important system that the body relies upon to deactivate and eliminate toxins and steroid hormones. Glucuronidation is a conjugation process through which potentially carcinogenic environmental toxins, such as polycyclic aromatic hydrocarbons and nitrosamines, and excess steroid hormones are neutralized.

amni® original formula

A Dietary Supplement
90 Capsules

More Info:

During glucuronidation, the enzyme glucuronosyl transferase catalyzes the conjugation of free carcinogens and steroid hormones to glucuronic acid. The resulting glucuronide-bound toxins and hormones can then be safely excreted in bile and urine. The body also deconjugates glucuronide-bound end products. The release of glucuronide-bound substances is beneficial in some circumstances, for example, when the excretion of steroid hormones is undesirable. Yet, the deconjugation process, which works via the enzyme beta-glucuronidase, can result in the re-release of harmful toxins back into the body.

The benefits of calcium D-glucarate are realized indirectly through the action of its metabolite Dglucaro- 1,4-lactone, which inhibits the deconjugating enzyme beta-glucuronidase found in both blood and tissue. Inhibition of beta-glucuronidase causes a net increase in glucuronidation, and thereby enhances a primary detoxification pathway in the body. Animal studies have documented a decrease in B-glucuronidase activity in breast, liver, colon, skin, lung, and prostate tissue following oral administration of calcium Dglucarate.

Once ingested, Calcium D-glucarate is converted to Dglucaric acid in the presence of gastric HCl. The body normally maintains an equilibrium between D-glucaric acid and its two metabolites, D-glucaro-1,4-lactone and D-glucaro-6,3-lactone. Calcium D-glucarate provides a slow-release source of D-glucaro-1,4-lactone. When taken directly, D-glucaro- 1,4-lactone is metabolized quite quickly and is excreted from the body usually within 1-2 hours of its administration. Calcium D-glucarate, however, is metabolized slowly, remaining in the body for 5 or more hours after ingestion. This results in maintenance of stable levels of D-glucaro-1,4-lactone for long periods of time. D-glucaric acid is produced endogenously in small amounts. It is also present in some fruits and vegetables, including oranges, apples, grapefruit, broccoli and other cruciferous vegetables.

Ingredients:
Serving Size: 1 Capsule
Servings Per Container: 90

Amount Per Serving
Calcium ...63mg
(From 500 mg of Calcium D-Glucarate)

Contains:
Gelatin (capsule), Cellulose, Water, Magnesium Stearate

Dosage:
As a dietary supplement, adults take 1 to 2 capsules daily or as directed by your healthcare professional.

WARNINGS:
KEEP OUT OF REACH OF CHILDREN.

For optimal storage conditions, store in a cool, dry place.
(59º-77ºF/15º-25ºC)
(35-65% relative humidity)

Tamper resistant package, do not use if outer seal is missing.

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