FindWhy™ Genetic Testing for Weight Control looks at five genes that are known to have a significant impact on the metabolism of fats and carbohydrates and responsiveness to exercise. The genes in the Weight Control panel were selected following a very thorough and current review of research literature related to genes, exercise, obesity and nutrition. The genes (SNPs) tested are:
- FTO Regulation of metabolism and satiety
- MC4R Regulation of satiety and meal frequency
- ADRB2-E27Q Sensitivity to carbohydrates and stress impact
- FABP2-T55A Fat absorption and insulin regulation of sugar
- SH2B1 Regulation of insulin and leptin systems
Testing is performed on the DNA collected from on cheek cells which are obtained by brushing the three swabs on the inside of the mouth.
How does this work?
1. Purchase online
2. Doctors order provided by us.
3. Collect cheek swab at home and mail to the lab.
4. You receive the results.
5. Practitioner phone consultations available.
NOT AVAILABLE IN NEW YORK, CALIFORNIA, OR MD
Science has made great advances in understanding causes of obesity including identifying environmental causes as well as genes that might be implicated. Major scientific effort is now directed toward assessing the interactions of genes and environment in the current obesity epidemic. Obesity results when body fat accumulates over time as a result of a chronic energy imbalance (calories consumed exceed calories expended). Obesity is a major health hazard worldwide and is associated with several relatively common diseases such as diabetes, hypertension, heart disease, and some cancers.
In recent decades, obesity has reached epidemic proportions in populations whose environments offer an abundance of calorie-rich foods and fewer opportunities for physical activity. Although changes in the genetic makeup of populations occur too slowly to be responsible for this rapid rise in obesity, genes do play a role in the development of obesity. It is thought that genes regulate how our bodies capture, store, and release energy from food including the drive to overeat (poor regulation of appetite and satiety); the tendency to be sedentary (physically inactive); a diminished ability to use dietary fats as fuel; and an enlarged, easily stimulated capacity to store body fat.
Genetic information is stored in DNA. Segments of DNA that encode proteins or other functional products are called genes.
Genes are the basic physical and functional units of heredity. Each gene is located on a particular region of a chromosome. Adenine, thymine, guanine, and cytosine are nucleotides and are the building blocks of DNA. Each gene has a specific ordered sequence of these nucleotides.
A gene can exist in many different forms, called alleles. For example there is a gene which determines the color of hair. That gene may have many forms, or alleles: black hair, brown hair, auburn hair, red hair, blond hair, etc. One allele for each gene comes from the mother and one from the father.
Each of the two inherited alleles for a gene each may be strong ("dominant") or weak ("recessive"). When an allele is dominant, it means that the physical characteristic ("trait") it is coded for is usually expressed, or shown, in the living organism. Only one dominant allele is needed to express a dominant trait. Two recessive alleles are needed to exhibit a recessive form of a trait. Researchers investigate just what each gene is responsible for in the human body, and how mutations to genes cause genetic diseases.
The FindWhy™ test identifies DNA variations called single nucleotide polymorphisms (SNP’s) and is based on a detailed analysis of the scientific literature. This test is a risk assessment test and is not a diagnostic test. The test does not guarantee weight loss by following a particular dietary strategy, nor does it provide obvious benefit from choosing one diet over another based on the test results. This test is designed to shed light on an individual's genetic background, and therefore allow patients to create a weight loss plan that will help overcome possible predispositions, and to help them achieve lasting results.