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Involved in inflammatory and immune responses, histamine is most commonly known for its role in allergic reactions. As a neurotransmitter, histamine acts as a neuromodulator, since it regulates the release of several other neurotransmitters in the brain, and can affect your emotions, behavior and sleep cycles. High histamine levels in the brain may be a factor in addictive behaviors, depression, headaches, and degenerative diseases, while low histamine levels may contribute to fatigue, paranoia, low libido, and seizures.