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Cyrex Array 2 Intestinal Permeability Screen

Leaky Gut Test Cyrex Array 2
Increased permeability of the intestinal barrier to macromolecules is associated with a variety of local and systemic inflammatory conditions. Intestinal
permeability can cause systemic inflammation,which can then sustain itself by its ongoing effect on the gut.
The target tissue damage is primarily determined by genetics and exposure of environmental factors,leading to various clinical conditions including:
Gluten Sensitivity and Celiac disease
Food Allergies
Inflammatory bowel disease (Ulcerative Colitis and Crohn’s disease)
Numerous autoimmune diseases (Rheumatoid Arthritis, Psoriasis, Type 1 Diabetes,Spondylitis, etc.)
Neurological conditions (Multiple Sclerosis, Guillain Barré Syndrome, etc.)
Cognitive Dysfunction (depression, anxiety, Schizophrenia, etc.)
Ready to find out if you have leaky gut?
  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for a blood draw at a local lab or mobile draw at your home. Draw fee may apply.
  • You receive the results by email within 2-3 weeks.
  • Practitioner phone consultations available for an additional fee.


Patient Name

The patient's name is required for all test kit purchases

Date of Birth

The patient's Date of Birth is required for all test kit purchases


Add-ons total:



Intestinal Antigenic Permeability Screen Requires a blood draw.

Elevated antibodies to LPS, Occludin/Zonulin and the Actomyosin Network are patent pending biomarkers that identify the breakdown of a healthy in
testinal barrier, which allow penetration of largeantigenic molecules:
1.Lipopolysaccharides (LPS) are large molecules found in gram-negative bacteria. They are endotoxins, and if absorbed, elicit a strong immune response.The detection of antibodies against LPS reveals macromolecule-sized endotoxin infiltration through the intestinal barrier into the systemic circulation.
2.Occludin is part of the main component of proteins holding together the tight junctions. The detection of antibodies to occludin indicates that the tight junctions are breaking down. This is a measure of a mechanism involved in dama ging the intestinal barrier membrane.
3.Zonulin, a protein, regulates the permeability of the intestine. The detection of antibodies against zonulin indicates that the normal regulation of tight junctions is compromised. This can be a clue to presence of an ongoing mechanism involved in damaging the intestinal barrier.
4.The Actomyosin Network, a protein complex, regulates intestinal barrier function by maintaining the plasticity of tight junctions.
Antibodies to the actomyosin network are a biomarker of intestinal barrier dysregulation via cell infiltration. For example, 98.2% of Celiac disease patients
with flat mucosa have antibodies to actin.This is a measure of mechanism involved in damaging the intestinal barrier.
Actomyosin IgA ( CPT CODE : 86256 )
Occludin/Zonulin IgG ( CPT CODE : 86256-59 )
Occludin/Zonulin IgA ( CPT CODE : 86256-59 )
Occludin/Zonulin IgM ( CPT CODE : 86256-59 )
Lipopolysaccharides (LPS) IgG ( CPT CODE : 86256-59 )
Lipopolysaccharides (LPS) IgA ( CPT CODE : 86256-59 )
Lipopolysaccharides (LPS) IgM ( CPT CODE : 86256-59 )


Cyrex Labs

Cyrex Labs

Meet Dr. Dave

Dr. David Scheiderer MD, MBA, DFAPA, is the Chief Medical Officer and Director of Education at Integrative Psychiatry, Inc. in Sarasota, Florida and the President of Tiberius Enterprises, Inc. in Roanoke, Virginia. An accomplished clinician, educator, and lecturer, Dr. Dave has established himself as a key opinion leader in the fields of both mainstream psychiatry and functional medicine. Dissatisfied with the patient outcomes using only conventional treatments, he began treating his patients by addressing biological imbalances with lifestyle improvements, nutrition and nutraceuticals to get better outcomes. His integrative approach provided much improved results. Dr. Dave is passionate about helping the community he serves by personalizing treatments and educating the public about mental health and healthy aging. He has formulated several of our supplements and sat on the advisory board for many others, ensuring the products we carry are based on science and experience and have the best efficacy rates and highest ingredient quality available.

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