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Doctor's Data Urine Porphyrins

Doctor´s Data Urine Porphyrins are oxidized intermediate metabolites of heme biosynthesis and have been associated with genetic disorders, metabolic disturbances/diseases, poor nutritional status, oxidative stress, and high level exposure to toxic chemicals or metals. Specific urine porphyrin profiles are associated with high level exposure to mercury, arsenic, lead and some toxic chemicals. Precoproporphyrins are reported separately and per unit uroporphyrin to increase detection even when heme production is very low.

  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab.
  • You receive the results by email within 2-3 weeks.
  • Got insurance? Some tests are covered. Call 800 385-7863 for more information.


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Urinary porphyrins are oxidized intermediate metabolites of heme biosynthesis and are readily excreted in excess when porphyrinogens accumulate as a result of inhibition of specific enzymes in the heme biosynthetic pathway. Heme is required for oxygen binding, transport and utilization, cytochromes, and electron transport in mitrochondira. The high rate of production of heme facilitates the use of urinary porphyrins as early and sensitive biomarkers of disorders in heme production, and has long been associated with genetic disorders, metabolic disturbances/diseases, nutritional status, oxidative stress, and high level exposure to toxic chemicals or metals.


Specific urinary porphyrin profiles have been associated with very high levels of toxic metals such as mercury (Hg), lead and arsenic. Mercury specifically inhibits two enzymes in porphyrinogen metabolism: uroporphyrinogen decarboxylase and coproporphyrinogen oxidase (CPOX). Inhibition of those two enzymes, particularly in the renal cortex, results in accumulation of pentacarboxyporphyrinogen and coproporphyrinogen III. Oxidation of the abnormally elevated porphyrinogens results in elevated urinary levels of total porphyrins, pentacarboxyporphyrin and coproporphyrin III. Recent research has identified an additional abnormal porphyrin in the urine of Hg-exposed dentists and also in rats fed very high levels of mercury for extended periods of time. A third Hg-associated porphyrin is most commonly referred to as “precoproporphyrin” as it elutes after pentacarboxyporphyrin and before coproporphyrin I. The recently described precoproporphyrin has yet to be characterized with respect to molecular identity and appears to be elevated in Hg exposed individuals who carry a variant of the CPOX gene (CPOX4 polymorphism). Research at Doctor’s Data, Inc. has identified three separate precoproporphyrin peaks. Since knowledge about the Hg-associated precoproporphyrin entities is limited, we report the levels of all three peaks separately, as well as the total, for research use. Since uroporphyrin levels are not known to be affected by Hg, we also report the total precoproporphyrins-to-uroporphyrin ratio to increase the sensitivity for detecting abnormalities in individuals with low heme biosynthesis as may occur in children with nutritional deficiencies and/or autism.


Arsenic exposure has been associated with elevated levels of uroporphyrins and coproporphyrin I, and an elevated ratio of coproporphyrins (I: III). Lead exposure has been associated with elevated levels of coproporphyrin III.


Exposure to hexachlorobenzene and dioxin has been associated with elevated levels of uroporphyrins. Exposure to polyvinylchloride (PVC) and polybrominated biphenyl has been associated with elevated levels of coproporphyrins.


Various drugs and other substances can suppress enzymes involved in porphyrin metabolism and affect the levels of urinary porphyrins. Such compounds include alcohol, sedatives, analgesics, antibiotics, estrogens, and oral contraceptives. Anemia, pregnancy, and liver disease can also affect porphyrin metabolism.


The Urine Porphyrins test is best used in conjunction with urine toxic metals pre- and post-provocation testing.


Doctors Data Lab

Doctors Data has over 30 years’ experience, provides specialty testing to healthcare practitioners around the world.  DDI’s tests are utilized in the assessment, detection, prevention, and treatment of heavy metal burden, nutritional deficiencies, gastrointestinal function, hepatic detoxification, metabolic abnormalities, and diseases of environmental origin. A specialist and pioneer in essential and toxic elemental testing of multiple human tissues, the laboratory offers a wide array of functional testing. You receive the results, no doctors order needed! (Labrix Laboritories products are now part of Doctors Data Lab.)
Doctors Data Lab

Meet Dr. Dave

Dr. David Scheiderer MD, MBA, DFAPA, is the Chief Medical Officer and Director of Education at Integrative Psychiatry, Inc. in Sarasota, Florida and the President of Tiberius Enterprises, Inc. in Roanoke, Virginia. An accomplished clinician, educator, and lecturer, Dr. Dave has established himself as a key opinion leader in the fields of both mainstream psychiatry and functional medicine. Dissatisfied with the patient outcomes using only conventional treatments, he began treating his patients by addressing biological imbalances with lifestyle improvements, nutrition and nutraceuticals to get better outcomes. His integrative approach provided much improved results. Dr. Dave is passionate about helping the community he serves by personalizing treatments and educating the public about mental health and healthy aging. He has formulated several of our supplements and sat on the advisory board for many others, ensuring the products we carry are based on science and experience and have the best efficacy rates and highest ingredient quality available.

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