amni® original formula
A Dietary Supplement
During glucuronidation, the enzyme glucuronosyl transferase catalyzes the conjugation of free carcinogens and steroid hormones to glucuronic acid. The resulting glucuronide-bound toxins and hormones can then be safely excreted in bile and urine. The body also deconjugates glucuronide-bound end products. The release of glucuronide-bound substances is beneficial in some circumstances, for example, when the excretion of steroid hormones is undesirable. Yet, the deconjugation process, which works via the enzyme beta-glucuronidase, can result in the re-release of harmful toxins back into the body.
The benefits of calcium D-glucarate are realized indirectly through the action of its metabolite Dglucaro- 1,4-lactone, which inhibits the deconjugating enzyme beta-glucuronidase found in both blood and tissue. Inhibition of beta-glucuronidase causes a net increase in glucuronidation, and thereby enhances a primary detoxification pathway in the body. Animal studies have documented a decrease in B-glucuronidase activity in breast, liver, colon, skin, lung, and prostate tissue following oral administration of calcium Dglucarate.
Once ingested, Calcium D-glucarate is converted to Dglucaric acid in the presence of gastric HCl. The body normally maintains an equilibrium between D-glucaric acid and its two metabolites, D-glucaro-1,4-lactone and D-glucaro-6,3-lactone. Calcium D-glucarate provides a slow-release source of D-glucaro-1,4-lactone. When taken directly, D-glucaro- 1,4-lactone is metabolized quite quickly and is excreted from the body usually within 1-2 hours of its administration. Calcium D-glucarate, however, is metabolized slowly, remaining in the body for 5 or more hours after ingestion. This results in maintenance of stable levels of D-glucaro-1,4-lactone for long periods of time. D-glucaric acid is produced endogenously in small amounts. It is also present in some fruits and vegetables, including oranges, apples, grapefruit, broccoli and other cruciferous vegetables.
Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving
(From 500 mg of Calcium D-Glucarate)
Gelatin (capsule), Cellulose, Water, Magnesium Stearate
As a dietary supplement, adults take 1 to 2 capsules daily or as directed by your healthcare professional.
KEEP OUT OF REACH OF CHILDREN.
For optimal storage conditions, store in a cool, dry place.
(35-65% relative humidity)
Tamper resistant package, do not use if outer seal is missing.