Due to increased demand, please allow for an extra 3-4 days to process orders.
Until further notice, all sales are final (no returns) due to circumstances created by COVID-19.


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Estrogen Metabolism Plus by Genova Diagnostics

Metabolism Plus is a comprehensive urinary estrogen metabolism evaluation designed to assist in the prevention and treatment of estrogen-related symptoms and conditions. This provides clues about menstrual irregularities, infertility, endometriosis, breast cancer, prostate cancer, and osteoporosis.

  • Purchase on our secure website.
  • Lab order is provided by us.
  • You receive a collection kit for saliva, urine, or finger stick to collect at home and mail to the lab. Some tests require a blood draw at a local lab.
  • You receive the results by email within 2-3 weeks.
  • Got insurance? Some tests are covered. Call 800 385-7863 for more information.


Patient Name

The patient's name is required for all test kit purchases

Date of Birth

The patient's Date of Birth is required for all test kit purchases


Add-ons total:



Estrogen Metabolism Plus is ideal for:
• The prevention and treatment of hormone-related symptoms and conditions
• Prescribing and monitoring Hormone Replacement Therapy (HRT)
• Assessing the risk of hormone-related disease, including breast cancer

Analytes tested:

2:16 Ratio
2-Methoxyestrone:2-Hydroxyestrone Ratio
4-Methoxyestrone:4-Hydroxyestrone Ratio

The Benefits of Urine Hormone Testing:

First-Morning-Void OR 24-hour urine collection
These simple, at-home collection options offer the advantage of a time average, effectively
integrating spikes that may occur in these hormones over time.
Measures the free, bio-available fraction of hormones
Urinary testing measures the portion of hormones that are active in the body.
Measures the metabolites of these important steroid hormones
These metabolites contribute to provide a robust analysis of hormonal excess or deficiency,
and help to assess the adequacy and safety of hormone replacement therapy (HRT).
Anabolic/Catabolic Balance (ACB)
The ACB evaluates the ability for “growth and healing” (anabolic) versus the state of
“wear and tear” (catabolic).
Methylation Capacity
Methylation is required for effectively eliminating carcinogenic hormone metabolites,
and for activating protective hormones against cancer.

Therapy is directed at the source of the abnormality, which may include:
• HRT – estrogen, progesterone, androgens, thyroid, cortisol, etc.
• Estrogen Metabolism support – Indole-3-carbinol (I3C) and/or Diindolemethane (DIM)

Before Taking this Test:
Premenopausal women, note date of menstrual cycle on the requisition.

Recommend women on HRT or hormonal contraceptives, to obtain specimen approximately
8-10 hours AFTER the last dose.


Genova Diagnostics

We are proud to offer testing from Genova Diagnostics. They provide functional lab testing that focuses on finding the cause of your problems not just treating the symptoms. Many of these test focus prevention by arming you with the knowledge of what lifestyle changes you need to make in order to stop or slow the progression of heart disease, diabetes, auto immune disease and many more. Genova Labs has now merged with Metametrix so you get two great labs in one! How does this work?
  1. Purchase online
  2. Lab order provided by us.
  3. Collect saliva, urine, or fingerstick at home and mail to the lab. Some tests require blood draw at a lab of your choosing.
  4. You receive the results by email within 2-3 weeks.
  5. Practitioner phone consultations available, some included with test.
Not available in MD. Some tests not available in NY. How do I know what test I need?
  • If you are already working with a practitioner ask them.
  • Get recommendations from our wellness practitioners with a phone consultation.
  • Check out our Genova Test Selection Guide
Genova Diagnostics

Meet Dr. Dave

Dr. David Scheiderer MD, MBA, DFAPA, is the Chief Medical Officer and Director of Education at Integrative Psychiatry, Inc. in Sarasota, Florida and the President of Tiberius Enterprises, Inc. in Roanoke, Virginia. An accomplished clinician, educator, and lecturer, Dr. Dave has established himself as a key opinion leader in the fields of both mainstream psychiatry and functional medicine. Dissatisfied with the patient outcomes using only conventional treatments, he began treating his patients by addressing biological imbalances with lifestyle improvements, nutrition and nutraceuticals to get better outcomes. His integrative approach provided much improved results. Dr. Dave is passionate about helping the community he serves by personalizing treatments and educating the public about mental health and healthy aging. He has formulated several of our supplements and sat on the advisory board for many others, ensuring the products we carry are based on science and experience and have the best efficacy rates and highest ingredient quality available.

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