Biotinase deficiency, an inborn error of metabolism in autism and Rett’s syndrome, is dependent on Zinc. Biotinase helps to break down peptides, including those with opiate-type reactivity.
Combining zinc supplementation with cimetidine (Tagamet) has proven to be very successful in the treatment of recurrent infections in patients with immune deficiency
(Int J Clin Lab Research 27: 79-80, 1997)
2 mL of serum drawn into a royal blue-topped no additive tube is the absolute minimum. The serum must be removed from the specimen within 4 hours of collection.